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Publications on CULTEX Technology |
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Exp Toxicol Pathol. 2016 May;68(5):255-61
"Challenge for 3D culture technology: Application in carcinogenesis studies with human airway epithelial cells."
Authors: M. Emura, M. Aufderheide
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IIVS 2016, Bethesda
"Ciliatoxicity in immortalized human primary bronchiolar epithelial cells after repeated air-liquid interface exposure to e-cigarette vapor and native mainstream smoke of K3R4F cigarettes."
Authors: M. Aufderheide, S. Scheffler, N. Möhle
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Exp Toxicol Pathol. 2015 Oct 24. pii: S0940-2993(15)30024-5
"A new computer-controlled air-liquid interface cultivation system for the generation of differentiated cell cultures of the airway epithelium."
Authors: M. Aufderheide, C. Förster, M. Beschay, D. Branscheid, M. Emura
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Int. J. Environ. Res. Public Health 2015, 12(10), 12466-12474
"Cytotoxic Evaluation of e-Liquid Aerosol using Different Lung-Derived Cell Models."
Authors: S. Scheffler, H. Dieken, O. Krischenowski, M. Aufderheide
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CORESTA 2015, Jeju Island, South Korea
"A new in vitro testing module for the cytotoxic evaluation of e-cigarette vapor."
Authors: S. Scheffler, H. Dieken, N. Möhle, M. Aufderheide, T. Schmidt
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Toxicology Letters 2015 Sep 7. pii: S0378-4274(15)30040-0
"Optimization of the CULTEX® radial flow system for in vitro investigation of lung damaging agents."
Authors: A. Tsoutsoulopoulus, N. Möhle, M. Aufderheide, A. Schmidt, H. Thiermann, D. Steinritz
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Experimental and Toxicologic Pathology 2015; doi:10.1016/j.etp.2015.04.006
"Ciliatoxicity in human primary bronchiolar epithelial cells after repeated exposure at the air-liquid interface with native mainstream smoke of K3R4F cigarettes with and without charcoal filter"
Authors: M. Aufderheide, S. Scheffler, S. Ito, S. Ishikawa, M. Emura
Download PDF on Science Direct
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Int. J. Environ. Res. Public Health 2015, 12(4), 3915-3925
"Evaluation of E-Cigarette Liquid Vapor and Mainstream Cigarette Smoke after Direct Exposure of Primary Human Bronchial Epithelial Cells"
Authors: S. Scheffler, H. Dieken, O. Krischenowski, C. Förster, D. Branscheid, M. Aufderheide
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Experimental and Toxicologic Pathology 2015; 67(2):81-88
"Target cell types with stem/progenitor function to isolate for in vitro reconstruction of human bronchiolar epithelia"
Authors: M. Emura, M. Aufderheide, U. Mohr
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IIVS 2014, Bethesda
"The CULTEX® RFS Compact: the next generation of CULTEX® systems for the direct exposure of cells at the air-liquid interface."
Authors: N. Möhle, S. Scheffler, H. Dieken, O. Krischenowski, M. Aufderheide
Download poster
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Journal of Applied Toxicology 2014; 34:506-515
"Direct exposure at the air-liquid interface: evaluation of an in vitro approach for simulating inhalation of airborne substances"
Authors: J. Rach, J. Budde, N. Möhle, M. Aufderheide
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Chemico-Biological Interactions 2013; 206:479-490
"Use of the Cultex® Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility"
Authors: D. Steinritz, N. Möhle, C. Pohl, M. Papritz, B. Stenger, A. Schmidt, C. J. Kirkpatrick, H. Thiermann, R. Vogel, S. Hoffmann, M. Aufderheide
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Experimental and Toxicologic Pathology 2013; 65:1183–1193
"A review of in vitro cigarette smoke exposure systems"
Authors: D. Thorne, J. Adamson
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Experimental and Toxicologic Pathology 2013; 65:973-978
"Importance of material evaluation prior to the construction of devices for in vitro techniques"
Authors: J. Rach, B. Halter, M. Aufderheide
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Eurotox 2013, Interlaken
"An automated system for a stable and reproducible long-term cultivation of epithelial cells at the air-liquid interface The CULTEX® LTC module"
Authors: M. Aufderheide, N. Möhle, J. Rach, B. Halter
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Experimental and Toxicologic Pathology 2013; 65:683-688
"Detection of the cytotoxicity of water-insoluble fraction of cigarette smoke by direct exposure to cultured cells at an air-liquid interface"
Authors: H. Nara, Y. Fukano, T. Nishino, M. Aufderheide
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IVTIP 2013, Southhampton
"Prevalidation of the CULTEX® method (BMBF project 0315710): The air-liquid interface exposure of human lung cells in the CULTEX® Radial Flow System (RFS)"
Authors: N. Möhle, D. Steinritz, C. Pohl, S. Hoffmann, M. Aufderheide
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BioMed Research International 2013; 2013:73413
"The CULTEX® RFS: a comprehensive technical approach for the in vitro exposure of airway epithelial cells to the particulate matter at the air-liquid interface"
Authors: M. Aufderheide, B. Halter, N. Möhle, D. Hochrainer
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Toxicology In Vitro 2011; 25:2080-2087
"Toxic effects following phosgene exposure of human epithelial lung cells in vitro using a CULTEX® system"
Authors: D. Wijte, M. J. Alblas, D. Noort, J. P. Langenberg, H. P. van Helden
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Journal of Aerosol Science 2011; 42:668-692
"In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung – A dialog between aerosol science and biology"
Authors: H-R. Paur, F. R. Cassee, J. Teeguarden, H. Fissan, S. Diabate, M. Aufderheide, W. G. Kreyling, O. Hänninen, G. Kasper, M. Riediker, B. Rothen-Rutishauser, O. Schmid
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Eurotox 2011, Paris
"Importance of biomaterials testing prior to the construction of devices for in vitro techniques"
Authors: J. Rach, M. Aufderheide
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Eurotox 2011, Paris
"Prevalidation of the CULTEX® method: in vitro analysis of the acute toxicity of inhalable fine dusts and nanoparticles after direct exposure of cultivated human cells from the respiratory tract"
Authors: C. Pohl, N. Möhle, M. Papritz, D. Steinritz, U. Mohr, S. Hoffmann, C.J. Kirkpatrick, M. Aufderheide
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Journal of Water and Health 2011; 9:586-596
"Application of an optimized system for the well-defined exposure of human lung cells to trichloramine and indoor pool air"
Authors: C. Schmalz, H. G. Wunderlich, R. Heinze, F.H. Frimmel, C. Zwiener, T. Grummt
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Eurotox 2011, Paris
"Exposure of a human bronchial epithelial cell line with cigarette mainstream smoke in the CULTEX® Radial Flow System (RFS)"
Authors: D.-J. Budde, S. Scheffler, O. Krischenowski, M. Aufderheide
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Eurotox 2011, Paris
"Experimental study of aerosol cell exposure with an air-liquid interface"
Authors: M. Deutscher, N. Möhle, H. Bresch, S. Seeger, M. Aufderheide
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In vitro World Congress 2011, Montreal
"Pre-validation of the CULTEX® system assessing the acute inhalation toxicity of nanoparticles by direct exposure of cells via the air-liquid interface"
Authors: S. Hoffmann, N. Möhle, M. Papritz, C. Pohl, M. Aufderheide
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In vitro World Congress 2011, Montreal
"Need and Perspectives for the Implementation of Relevant In Vitro Methods in the Field of Inhalation Toxicology"
Authors: N. Möhle, J. Rach, S. Scheffler, D.-J. Budde, M. Aufderheide
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Analytical and Bioanalytical Chemistry 2011; 401:3213-3220
"Analytical in vitro approach for studying cyto- and genotoxic effects of particulate airborne material"
Authors: M. Aufderheide, S. Scheffler, N. Möhle, B. Halter, D. Hochrainer
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Fresenius Environmental Bulletin 2010 – PSP Volume 19, No. 8a
"A model to evaluate biological effects from combined exposure to UVA/B radiation and toluene"
Authors: M.G. Sacco, F. Pariselli, D. Rembges
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Experimental and Toxicologic Pathology 2010; 62:433-440
"In vitro micronucleus assay for cigarette smoke using a whole smoke exposure system: a comparison of smoking regimens"
Authors: K. Okuwa, M. Tanaka, Y. Fukano, H. Nara, Y. Nishijima, T. Nishino
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Experimental and Toxicologic Pathology 2011; 63:593-598
"Development of an in vitro exposure model for investigating the biological effects of therapeutic aerosols on human cells from the respiratory tract"
Authors: U. Deschl, J. Vogel, M. Aufderheide
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Experimental and Toxicologic Pathology 2009; 61:381-386
"Effects of toluene and benzene air mixtures on human lung cells (A549)"
Authors: F. Pariselli, M.G. Sacco, J. Ponti, D. Rembges
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Alternatives to Laboratory Animals 2009; 37:89-141
"In Vitro Models of Inhalation Toxicity and Disease"
Authors: K. BéruBé , M. Aufderheide, D. Breheny, R. Clothier, R. Combex, R. Duffin, B. Forbes, M. Gaca, A. Gray, I. Hall, M. Kelly, M. Lethem, M. Liebsch, L. Merolla, J-P. Morin, J. Seagrave, M.A. Swartz, T.D. Tetlay, M. Umachandran
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Alternatives to Laboratory Animals 2008; 36:591–598
"The Development of Novel Approaches to the Identificaton of Chemical and Protein Respiratory Allergens"
Authors: E. Roggen, M. Aufderheide, Y. Cetin, R.J. Dearman, S. Gibbs, I. Hermanns, I. Kimber, J.F. Regal, C. Rovida, D.B. Warheit, S. Uhlig
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Mutation Research 2008; 656:82–87
"Mutagenicity of Native Cigarette Mainstream Smoke and its Gas/Vapour Phase by Use of Different Tester Strains and Cigarettes in a Modified Ames Assay"
Authors: M. Aufderheide, H. Gressmann
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Experimental and Toxicologic Pathology 2008; 60:163–180
"An Efficient Approach to Study the Toxicological Effects of Complex Mixtures"
Author: Michaela Aufderheide
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Experimental and Toxicologic Pathology 2008; 60:213–224
"Statistical Analysis of In Vitro Data for Risk Assessment – Exemplified for a Case of Ames Test Data"
Authors: M. Roller, M. Aufderheide
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In vitro World Congress 2007, Tokyo
"A Modified Ames Assay, a Useful Tool for Analysing the Mutagenic Activity of Native Complex Atmospheres"
Authors: M. Aufderheide, H. Gressmann, U. Mohr
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Experimental and Toxicologic Pathology 2007; 58:383–392
"A Modified Ames Assay Reveals the Mutagenicity of Native Cigarette Mainstream Smoke and its Gas Vapour Phase"
Authors: M. Aufderheide, H. Gressmann
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Experimental Lung Research 2007; 33:27–51
"Responses of Differentiated Primary Human Lung Epithelial Cells to Exposure to Diesel Exhaust at an Air-Liquid Interface"
Authors: J. Seagrave, S. Dunaway, J. D. McDonald, J. L. Mauderly, P. Hayden, C. Stidley
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Inhalation Toxicology 2007; 19:13–22
"Cellular Mechanisms of Mainstream Cigarette Smoke – Induced Lung Epithelial Tight Junction Permeability Changes In Vitro"
Authors: D. S. Olivera, S. E. Boggs, C. Beenhouwer, J. Aden, C. Knall
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European Commission, Directorate-General, Joint Research Centre, Report EUR 22285 EN, 2006
"Dynamic in-vitro Exposure of Human Derived Cells to Indoor Priority Pollutants"
Authors: F. Pariselli, M. G. Sacco, D. Rembges
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WIT Transactions on Biomedicine and Health, Vol 10, 2006
"Set-up of a Dynamic in-vitro Exposure Device for the Study of Indoor Air Pollutant Effects on Human Derived Cells"
Authors: F. Pariselli, M. G. Sacco & D. Rembges
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Research Center Karlsruhe, October 2005
"Exposure System for Bioassays Measurement of the Toxicity of Airborne Nanoparticles"
Authors: H.R. Paur, S. Mülhopt, D. Diabaté
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April 23, 2005 Experimental and Toxicologic Pathology 2005, Supplement Issued July, 2005
"Experimental Assessment of the Toxicological Effects of Inhaled Complex Mixtures on the Respiratory System – Feasibility and Limitations"
Workshop 23–25 April 2005 in Barcelona, Spain
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