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- Literature
- Publications
- News
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IIVS 2016, Bethesda
"Ciliatoxicity in immortalized human primary bronchiolar epithelial cells after repeated air-liquid interface exposure to e-cigarette vapor and native mainstream smoke of K3R4F cigarettes."
Authors: M. Aufderheide, S. Scheffler, N. Möhle
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CORESTA 2015, Jeju Island, South Korea
"A new in vitro testing module for the cytotoxic evaluation of e-cigarette vapor."
Authors: S. Scheffler, H. Dieken, N. Möhle, M. Aufderheide, T. Schmidt
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Experimental and Toxicologic Pathology 2015; doi:10.1016/j.etp.2015.04.006
"Ciliatoxicity in human primary bronchiolar epithelial cells after repeated exposure at the air-liquid interface with native mainstream smoke of K3R4F cigarettes with and without charcoal filter"
Authors: M. Aufderheide, S. Scheffler, S. Ito, S. Ishikawa, M. Emura
Download PDF on Science Direct
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IIVS 2014, Bethesda
"The CULTEX® RFS Compact: the next generation of CULTEX® systems for the direct exposure of cells at the air-liquid interface."
Authors: N. Möhle, S. Scheffler, H. Dieken, O. Krischenowski, M. Aufderheide
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Eurotox 2013, Interlaken
"An automated system for a stable and reproducible long-term cultivation of epithelial cells at the air-liquid interface The CULTEX® LTC module"
Authors: M. Aufderheide, N. Möhle, J. Rach, B. Halter
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IVTIP 2013, Southhampton
"Prevalidation of the CULTEX® method (BMBF project 0315710): The air-liquid interface exposure of human lung cells in the CULTEX® Radial Flow System (RFS)"
Authors: N. Möhle, D. Steinritz, C. Pohl, S. Hoffmann, M. Aufderheide
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Eurotox 2011, Paris
"Importance of biomaterials testing prior to the construction of devices for in vitro techniques"
Authors: J. Rach, M. Aufderheide
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Eurotox 2011, Paris
"Prevalidation of the CULTEX® method: in vitro analysis of the acute toxicity of inhalable fine dusts and nanoparticles after direct exposure of cultivated human cells from the respiratory tract"
Authors: C. Pohl, N. Möhle, M. Papritz, D. Steinritz, U. Mohr, S. Hoffmann, C.J. Kirkpatrick, M. Aufderheide
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Eurotox 2011, Paris
"Exposure of a human bronchial epithelial cell line with cigarette mainstream smoke in the CULTEX® Radial Flow System (RFS)"
Authors: D.-J. Budde, S. Scheffler, O. Krischenowski, M. Aufderheide
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In vitro World Congress 2011, Montreal
"Pre-validation of the CULTEX® system assessing the acute inhalation toxicity of nanoparticles by direct exposure of cells via the air-liquid interface"
Authors: S. Hoffmann, N. Möhle, M. Papritz, C. Pohl, M. Aufderheide
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In vitro World Congress 2011, Montreal
"Need and Perspectives for the Implementation of Relevant In Vitro Methods in the Field of Inhalation Toxicology"
Authors: N. Möhle, J. Rach, S. Scheffler, D.-J. Budde, M. Aufderheide
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| Cultex Laboratories offers new routine toxicity test for e-liquid quality control. |
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E-cigarette liquids contain several components, which® are generally approved as food additives. However, the approval for oral use is not necessarily relevant for their inhalational use.
Flavors especially can bear unknown risks, if inhaled. A prominent example of such a flavor is butane-2,3-dione. It is harmless if it is used as butterscotch flavor in confectionery and consumed orally. But after inhalation, it can cause bronchiolitis obliterans, a serious disease also known as the ‚popcorn lung'.
In order to learn more about the effects after inhalational use, a test system is required which resembles the exposure situation in the human body as closely as possible.
The direct exposure of living human bronchial epithelial cells with e-cigarette vapor can reveal toxic components in e-cigarette liquids and therefore protect the consumer as well as the liquid manufacturer.
In vitro tests using human bronchial epithelial cells represent the situation in the human lung more closely, than studies in rodents do. In addition, in vitro tests are less time-consuming and costly than the respective animal studies.
Read more about our various testing methods in our leaflet:
Download PDF
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